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THURSDAY, MARCH 26
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Greet VAN DEN BERGHE

Tight glucose control: Yes or no?

The debate about tight glucose control continues. Hyperglycemia is associated with increased mortality but does achieving normoglycemia influence outcomes? In the opening session of this ISICEM, Dr Finfer presented results from the much awaited NICE-SUGAR study, showing an increased 90-day mortality in patients managed according to a tight glucose control protocol. Yesterday, he discussed further the results of this trial and speculated on some of the reasons for the differences among the different studies, and how to incorporate these results into the current body of evidence. Dr Van den Berghe presented findings from a recent single-center randomized controlled study of tight glucose control in the pediatric population which included 700 children and infants. There were considerably more episodes of hypoglycemia in the tight control group but the primary endpoint of ICU length of stay was reduced as were secondary endpoints of organ dysfunction and mortality. Drs Jean-Charles Preiser and Duncan Young presented data on the harmful effects of glucose variability and Dr Taylor Thompson highlighted the important place computerized algorithms could have in the protocolized management of blood glucose levels.  


Don't miss our social event this evening!

Ninth Art is an important part of Belgian culture so what better place for our key Symposium social event than the new "hot spot", Nine City, a museum dedicated to the comic strip!  

 

 

 



 

 



Expert Panel Address Burning Questions Regarding the Treatment of Invasive Fungal Infections


One of the highlights of yesterday’s program at the 29th ISICEM was a highly informative and stimulating satellite symposium sponsored by Astellas Pharma Europe Ltd. This symposium took the format of an interactive discussion and debate and provided the opportunity for the audience to hear expert opinion on the most pertinent clinical challenges faced by ICU physicians when treating invasive Candida infections.


Pertinent clinical challenges


The panel of experts who led the discussion, David Denning, Oliver Cornely and Olivier Lortholary, all specialize in the management of serious Candida or yeast infections. The burning questions they addressed included: issues with fluconazole prophylaxis; the significance of Candida epidemiology; guidance for catheter removal; and the importance of having agents available for patients with renal impairment or failure.


Abstract books available at exhibition stand


If you missed the opportunity to attend this symposium then please visit the Astellas Pharma Europe Ltd. exhibition stand where symposium abstract books are available. In addition, the exhibition stand has a number of interesting educational elements relating to the treatment of serious infections in the ICU, including interactive scientific panels and a slide selector resource.

 


 
Less sedation or sedationless?

Sedative agents have been widely used in ICU patients over the years but the current tendency is very much in favor of reducing sedation and even trending towards no sedation in appropriate patients. The potentially detrimental effects of sedation on various parameters, including patient-ventilator interactions, patient communication and mobility, ICU-acquired delirium and longer-term cognitive function were highlighted in a session on minimizing sedation yesterday morning. Dr Charles Brudney discussed the scores currently available for assessing sedation and Dr John Kress presented the arguments for daily awakening of patients. If we are to eliminate or reduce sedative agents, adequate analgesia is critical and different techniques of achieving good pain control were presented by Dr Jean-François Payen while Dr Martin Westphal focused on the beneficial effects of thoracic epidural analgesia.


Dr John KRESS


Become an ESICM Member

Membership benefits: Intensive Care Medicine Journal, PACT, saving on major ESICM activities, discount on international meetings endorsed, ESICM Book, ECCRN,

Special price for first application. Visit our website www.esicm.org  >> Membership / Our members / Benefits.

 

 

 
   
 
 

 

InSpectra™ StO2 Tissue Oxygenation Monitor
Noninvasive, Continuous, Real time and Direct Perfusion Status Monitoring.

Learn more about this technology during the sessions:

« Monitoring of tissue perfusion »
26 March Erasmus Room H: 8.30/ 10.00
Monitoring StO2 in traumatic shock
Jacques Duranteau (Le Kremlin-Bicêtre, France)
Monitoring StO2 in heart failure
Rüdger Kopp (Aachen, Germany)
Monitoring StO2 in sepsis
Jacques Creteur (Brussels, Belgium) 

« Cardiovascular monitoring » 
26 March Erasmus Room H : 13.30/ 15.30
StO2 monitoring
Nathan  Shapiro (Boston, United States) 

Or visit Hutchinson Technology Stand N. 36/ 37 Hall 11


Massive blood loss: Does rFVIIa help?


Trauma is frequently associated with massive bleeding and one third of trauma deaths are due to infractory hemorrhage. Dr Bertil Bouillon presented the results of a recent prospective, randomized, double-blinded, multi-center, placebo-controlled trial of rFVIIa (the CONTROL study) in patients with active hemorrhage due to trauma who had already received 4-8 units of RBCs. The trial was stopped for likely futility at interim analysis after inclusion of 573 patients and 30- and 90-day mortality and morbidity rates were indeed similar in treatment and placebo groups. However, rFVIIa-treated patients did have significantly lower transfusion requirements than placebo-treated patients both after blunt trauma and penetrating trauma. The placebo mortality rate was lower than expected (11% for blunt trauma and 13% for penetrating trauma) and Dr Bouillon suggested that the lack of a beneficial effect on survival or multiple organ failure outcomes may have been related to this fact and that further studies are needed to better determine which patients could best benefit from the blood-sparing properties of this agent.


Novel therapies for acute severe hypertension.
 

Marked blood pressure elevations and acute target-organ damage require immediate therapy as suggested by the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7). The pharmacologic agents used to treat acute severe hypertension are beta-adrenergic blockers, vasodilators, or both. This presentation reviewed novel pharmacologic approaches to treat vascular dysfunction and acute severe hypertension, and review recent advances and clincial trials including novel pharmacologic approaches.


 

LidCO, PiCCO, PRAM, NICOM, …. too many tools?


Dr Michael PINSKY
Measuring cardiac output is an essential part of hemodynamic monitoring in ICU patients. With increased concerns about the use of invasive techniques to measure cardiac output, notably the pulmonary artery catheter, the search has been on to discover less-invasive means of measurement and recent years has seen an influx of new methods, many making competing claims, leaving the clinician somewhat confused as to which is best. In a session dedicated to this issue, Dr Richard Beale first put this very clinically relevant topic into perspective by highlighting what is needed from a cardiac output monitor and offering a brief synopsis of how to compare the different techniques without an accepted “gold standard”. The invited faculty then presented some of the currently available systems. Dr Javier Belda pointed out that non-invasive techniques can also have limitations and complications, and finally Dr Michael Pinsky and Dr Jukka Takala summarized the indications for cardiac output monitoring and its clinical applications.

Keeping the right balance: Challenging current perceptions in volume replacement

Many solutions for perioperative volume replacement therapy contain non-physiological levels of sodium and chloride and are associated with metabolic acidosis and organ dysfunction. Using physiologically balanced crystalloids and colloids in a ‘total balanced volume replacement’ approach may reduce the risk of metabolic disturbance and provide better care for patients.1

On Wednesday, 25 March, Baxter welcomed delegates to ‘Keeping the right balance: Challenging current perceptions in volume replacement’, a symposium that featured three leading European experts discussing the optimisation of volume replacement therapy for improved clinical outcomes.

Professor Joachim Boldt chaired the event and presented an overview of ‘total balanced volume replacement’ and its implications for clinical practice. New British guidelines on intravenous fluid therapy recommend using balanced fluids for volume replacement. Professor Dileep Lobo explained the rationale for the guidelines and discussed the importance of distinguishing between fluid replacement and fluid maintenance in clinical practice. In his presentation ‘Back to basics: the physiological impact of volume replacement therapy on the microcirculation’, Professor Can Ince highlighted the importance of the microcirculation in organ function and how a greater understanding of this system may help to improve treatment for hypovolaemia.

Boldt J. The balanced concept of fluid resuscitation. Br J Anaesth 2007;99:312–5.

 

 

 

Welcome to the Baxter stand

We would be pleased to welcome you at the Baxter exhibition booth in Hall 7
(booth no. 07.029-07.032).

  • Join us for a coffee and a freshly baked Belgian waffle.
  • Take part in our interactive quiz about nutrition facts.
  • Learn about Baxter’s volume replacement therapy.
  • Do you know your current MRSA (Methicillin resistant Staphylococcus aureus) status?

Get your free MRSA status check at the Baxter booth.
It’s an easy 2 minutes nasal swab. You will get an accurate result from DNA based testing. You will be assigned a number to make the test completely anonymous. Give enhanced patient care by combining good aseptic technique and Baxter’s novel technology.

Looking forward to seeing you at the Baxter booth.
 
 
This is just a small selection of the many sessions held yesterday.
For our full program visit www.intensive.org